In all the POF patients, SOD and GPx activities were significantly ( p 0.05) than control group. Inter-element association between Zn and Se was significant in POF ( r = − 0.39, p = 0.02) compared to control group ( r = − 0.078, p = 0.65). Estrogen levels were negatively correlated with all the studied trace elements. FSH and LH levels were negatively correlated with Zn and Cu levels and positively correlated with Se levels. However, Se:Cu ratio was not significant between the groups. POF group had significantly lower levels of Zn, Cu, Se, and Zn:Cu ratio. Serum levels of Se, Zn, and Cu were determined along with hormonal, OS, and immunological markers. This was a cross-sectional, case-control study, involving 65 participants divided into the POF ( n = 35) and control ( n = 30) groups. The aim of this study was to explore the involvement of trace elements, OS, and immunological parameters in POF. Adequate intake of trace elements is required for antioxidant property and immune defense mechanism. The risk of premature ovarian failure (POF) increases in association with alteration in immunological parameters and oxidative stress (OS).
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